State laboratory in Maryland plans to make a print run monkey pox strain more lethal in highly conflicting mouse studies.

The team wants to equip the dominant clade – which mainly causes the rash and flu-like symptoms – with genes from another strain that causes severe disease.

They hope the experiment will show how different genes make monkeypox more deadly and spur the development of better drugs and vaccines for humans.

It’s just a week away DailyMail.com revealed that a similar experiment with a hybrid strain of Covid was conducted at Boston University.

The latest monkeypox study is funded by the National Institute of Allergy and Infectious Diseases (NIAID), a research arm of the National Institutes of Health (NIH).

But according to Dr. Richard Ebright, a microbiologist at Rutgers University in New Jersey, the modified virus “poses an exceptionally high risk” to the public if it were to accidentally leak out.

The Maryland team says their work does not involve “amplifying” the pathogen because they are changing natural mutations rather than creating new ones, meaning the hybrid cannot be more lethal than existing clades.

But the news will no doubt surprise many Americans that such research continues in the US despite fears that such practices could have caused the pandemic.

More than 27,000 cases of monkeypox have been reported in the U.S. since the current outbreak began earlier this year

The Maryland study will involve extracting dozens of genes from the more serious class 1 monkeypox virus (pictured left) and inserting them into the less virulent class 2 virus. They will then infect mice with the hybrid virus and monitor the development of the disease.

The Maryland study will involve extracting dozens of genes from the more serious class 1 monkeypox virus (pictured left) and inserting them into the less virulent class 2 virus. They will then infect mice with the hybrid virus and monitor the development of the disease.

The Maryland team's work is led by NIAID scientist Bernard Moss at the agency's headquarters in Bethesda (shown)

The Maryland team’s work is led by NIAID scientist Bernard Moss at the agency’s headquarters in Bethesda (shown)

The Maryland team is led by NIAID scientist Bernard Moss at the agency’s headquarters in Bethesda.

This phase of the research will involve extracting dozens of genes from the more severe class 1 monkeypox virus and inserting them into the milder class 2 virus.

They will then infect mice with the hybrid virus and monitor the development of the disease.

Initially, the team tried to do the opposite: replace the genetic material in the less virulent clade with clade 1 to make it less lethal, but without success.

The current global outbreak has been confirmed to be caused by clade 2, a less lethal strain of monkeypox in West Africa that has a fatality rate of less than one percent.

Clade 1, meanwhile, kills one in 10 people it infects. It originates in the Democratic Republic of the Congo and is mainly distributed in the Congo River basin.

Monkeypox cases are down after peaking in the summer

Monkeypox cases are down after peaking in the summer

Biden promises to end virus manipulation research

The White House announced plans to crack down on virus manipulation research just days after DailyMail.com discovered similar research being conducted at Boston University.

In a national biosecurity strategy unveiled last week, the Biden administration laid out plans to prevent and respond to future biodisaster situations like the COVID-19 pandemic.

The report highlights the risk of “accidental biothreats” caused by accidents in biosafety laboratories working with dangerous pathogens.

last monday DailyMail.com revealed that Boston University’s National Laboratory for Emerging Infectious Diseases developed a hybrid strain of Covid with 80 percent mortality in mice.

Researchers have defended the work, arguing that it could advance our understanding of Covid and how to treat and vaccinate against it, but critics warn that the benefits do not outweigh the risks of potential leakage.

Biden’s biosecurity plans, released two days later on Oct. 19, said, “The United States has a responsibility to ensure that our technology, development, and aid programs do not increase this risk [a lab leak] unintentionally’.

The White House report also acknowledged that “the risk of laboratory accidents may increase as the number of laboratories worldwide conducts high-risk life science research and research with potential pandemic pathogens.”

There is no suggestion that the report is a response to the Boston University work, and DailyMail.com has reached out to the White House for comment.

But the report nods to the potential dangers of so-called “boost-of-function” research, where the virus becomes more dangerous or contagious so that scientists can anticipate potential outbreaks or develop treatments.

Boston University says their study did not lead to an increase in function because the original wild-type strain killed 100 percent of mice exposed to it, which they believe means their work actually reduced the virus’s lethality.

Researchers have outfitted the original Wuhan strain of Covid with the Omicron spike protein, a part that helps it invade cells and makes it more infectious. Critics say the combination of increased infectivity and mortality makes it dangerous.

The Maryland experiment was exempted when it was given the green light in 2018 because monkeypox did not meet the “potential pandemic pathogen” threshold.

For a pathogen to be considered a PRR, it must be widespread with the potential for uncontrolled spread and be highly dangerous.

But at that time there were outbreaks of monkey pox limited to Africa, and the virus did not spread easily between people.

U.S. cases have almost always involved imported animals or travelers who visited countries in Central or West Africa.

Now that monkeypox is widespread and more than 26,000 cases have been reported in the U.S., the National Institutes of Health (NIH) plans to review the work.

But the research still can’t qualify as an “improvement” on PPP, the agency says, because the team is using existing mutations.

Dr Ebright told DailyMail.com: “A laboratory-created monkeypox virus… deadlier than the monkeypox virus currently circulating in humans, could potentially overcome vaccine protection and is likely to spread beyond the population currently is at risk. to the general population.

“The risk-benefit ratio is essentially infinite, including potential existential risks.”

Amid growing concern about such experiments, the NIH and the Department of Health and Human Services met last month develop recommended rule changes to the NIH policy for the care and surveillance of potential pandemic agents.

Among the proposed changes is expanding what constitutes a “potential pandemic agent” to include those that are highly transmissible but less virulent, as well as those that are less transmissible but have more severe adverse outcomes.

The rule change, if passed next year, would impose tighter rules on the types of monkeypox virus research that must begin at the NIH.

The latest controversy surrounding risky monkeypox research comes amid years of fierce debate over the enhancement research that many believe led to the Covid pandemic.

The pandemic has shed light on risky research practices that the government has funded for decades, temporarily suspending in 2014 just three years later.

Loud debate about the merits of the boost continues to center on the unproven theory that the coronavirus escaped from a laboratory in Wuhan, China.

It comes after DailyMail.com revealed that a team at Boston University had developed a hybrid Covid virus – combining Omicron and the original Wuhan strains – which had an 80 per cent mortality rate in mice.

Boston University says their study did not lead to an increase in function because the original wild-type strain killed 100 percent of mice exposed to it, which they believe means their work actually reduced the virus’s lethality.

Researchers have outfitted the original Wuhan strain of Covid with the Omicron spike protein, a part that helps it invade cells and makes it more infectious.

Some experts have defended the work, arguing that it could advance our understanding of Covid and how to treat and vaccinate against it, but critics warn that the benefits do not outweigh the risks of potential leakage.

The hybrid strain caused immediate concern due to the combination of the worst characteristics of the virus – the high transmission rate of Omicron and the high mortality of the original.

https://www.dailymail.co.uk/health/article-11349241/Lab-Maryland-plans-create-hybrid-monkeypox-strain-contagious-lethal.html?ns_mchannel=rss&ns_campaign=1490&ito=1490