A new study suggests that fourth injections of Covid-19 give people protection “above and above” that they provide to people who have undergone three injections.

Research continues to assess the level of protection of people after vaccination, as well as the time during which this protection lasts.

A team of scientists led by University of Southampton tracked a group of people and their antibody levels and T cellsboth measures that indicate the level of protection of the person from the virus.

The CovBoost study also looked at side effects after the fourth stroke.

The study involved 166 people who offered blood samples, meaning researchers could study the concentration of antibodies in the blood.

They were investigated at various points in time, including 28 days after the third stroke; again just before their fourth reinforcement was introduced – which occurred on average just over 200 days later; and then 14 days after they received the fourth blow.

Antibody levels decreased between the third stroke and the fourth booster.

But two weeks after the enhancement stroke, the antibody level rose even higher than the level observed after the third stroke.

And there was a significant increase compared to the level seen on the day they received the fourth booster – participants had 12-16 times higher levels of antibodies in their blood two weeks after they received the fourth vaccination, compared to the day of its administration.

According to a study published in the journal The Lancet Infectious Diseases, an increase was also observed at the cellular level.

The researchers studied data on people taking two doses of AstraZeneca injections, after which Pfizer booster, who then received either a Pfizer injection, or half a dose of Moderna jab for his fourth vaccine.

They also looked at people taking three doses of Pfizer followed by a fourth injection of Pfizer or a half dose of Moderna injection.

No serious side effects were reported among the participants, some reported pain or fatigue.

But the authors said the study gave a “hint” that a small number of people could reach the “ceiling” in terms of the amount of protection they could receive from the fourth strike.

The authors stated that some people had a high level of immune response “even up to the fourth dose and had a limited increase from the fourth dose,” including people who had just been infected with the virus.

Lead trials Professor Sol Faust, director of the NIHR Center for Clinical Research in Southampton, said: “These results highlight the benefits of the most vulnerable people receiving current spring stimulants, and give confidence in any future autumn stimulus program in the UK if the Joint VAC Committee immunization considers it necessary at the time ”.

Health and Social Services Minister Sajid Javid added: “This is another piece of evidence that underscores the importance of people appearing for boosters as soon as they are eligible.

“We know how to live Coronavirus covid infection thanks to the protection provided by our phenomenal vaccine program, and the booster dose will boost your immunity to continue to protect you and your loved ones. ”

A number of groups have been called for spring stimulation, including for people aged 75 and older, people living in nursing homes, or people aged 12 and older who have a weakened immune system.

For most it will be the fourth dose of the vaccine, but for some with a weakened immune system it will be the fifth.

The new study supports a campaign to stimulate and will be used by experts who will decide on the future of the vaccination program – including whether people with weakened immune systems should make further injections and whether to deploy a vaccination program. include other groups.

So far in England alone more than three million people have received a spring stimulant, according to the NHS of England.

A study published in the journal Nature Communications concluded that Covid-19 injections in pregnant women are “safe” without increased risk to mothers and their children.

In a study led by experts from St. George’s University University and the Royal College of Obstetricians and Gynecologists, researchers looked at 23 studies that reported more than 117,000 pregnant women who received the Covid mRNA vaccine, a vaccine technology used at Pfizer. and Moderna injections.

The team found that the vaccines were safe and resulted in a 15% reduction in stillbirths.

Asma Khalil, a professor of obstetrics and maternity medicine at St. George’s, said: “This paper shows that vaccination against Covid-19 is both safe and effective, and we hope it will help reassure pregnant women to accept their vaccine offer. the future. ».


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