London [UK]May 17 (ANI): According to a new study, the risk of invasive breast cancer in men may be related to infertility in a male partner who expresses himself.
The results of the study were published in the open source journal Beast Cancer Research.
Breast cancer in men is less common than in women, and to date its association with infertility has only been investigated in small studies. Only one small study has suggested a possible link between men who give birth to children and breast cancer.
The authors surveyed 1998 men in England and Wales diagnosed with breast cancer, with 112 (5.6 per cent) also reporting infertility and 383 (19.2 per cent) having no children.
Authors from the Institute for Cancer Research (London, UK) investigated the potential relationship between self-inflicted infertility or the absence of children and the risk of breast cancer in men. Michael Jones and his colleagues surveyed 1998 men (under the age of 80) who were diagnosed with breast cancer between 2005 and 2017 and who lived in England and Wales. They were compared to 1,597 men as a control group who were not blood relatives. In the control group, 80 men reported infertility (5.0 percent).
The risk of invasive breast cancer tumors (cancer cells that spread beyond the site where they first formed) was significantly associated with male infertility on the basis of 47 individuals with breast cancer (2.6 percent) compared with 22 cancer-free control groups. but with infertility reported on its own (1,4). interest). The authors did not find a significant association between breast cancer risk and partner infertility or if the source of infertility was unknown.
In further studies, the authors observed a greater number of men with breast cancer (383 men) who had no children compared with the control group (174 men). However, the authors warn that the absence of children does not fully reflect male infertility, as men may not have children for a number of cultural and social reasons.
The associated risk of breast cancer with infertility or no children was not significant based on 160 individuals with in situ breast cancer tumors (cancer cells that did not spread beyond where they first formed) compared with 1,597 control groups.
Michael Jones, co-author, said: “Our data suggest that there may be a link between male infertility and invasive breast cancer in men.” The authors conducted additional sensitivity analysis to control alcohol consumption, smoking, family history of breast cancer. , and liver disease, in the case of potential confusion, but found no strong evidence that these factors influenced the results.
The authors did not control obesity, but excluded data from some analyzes of 11 men with Klinefelter syndrome, nine with previous cancer, 29 men with severe obesity, and 169 with Klinefelter syndrome. Three people born to a woman were not included in any of the analyzes.
The authors warn that fertility self-assessment has the potential for misclassification because fertility is a complex process that can involve both male and female factors. Men cannot report children out of wedlock or those they may not know about, or they may remain childless by choice. The authors suggest that confirmation of infertility through medical records, although impractical in this study, may reduce bias in memories in future studies.
Michael Jones added: “The causes of breast cancer in men are largely unknown, in part because it is rare and in part because previous studies have been small. The data presented in our study suggest that the link between infertility and Breast cancer needs to be confirmed by further necessary research and future research into potential underlying factors such as hormonal imbalance. ”(ANI)